Reduction of hyaluronan and increased expression of HYBID (alias CEMIP and KIAA1199) correlate with clinical symptoms in photoaged skin.

Hiroyuki YoshidaA NagaokaA KomiyaM AokiS NakamuraT MorikawaR OhtsukiT SayoY OkadaY Takahashi

Published in: The British journal of dermatology (2018)

These data demonstrate that imbalance between HYBID-mediated HA degradation and HAS-mediated HA synthesis may contribute to enhanced HA catabolism in photoaged skin, and suggest that HYBID-mediated HA reduction in the papillary dermis is related to skin wrinkling and sagging of photoaged skin.

Keyphrases

soft tissue
wound healing
poor prognosis
physical activity
sleep quality