Inducing expression of ICOS-L by oncolytic adenovirus to enhance tumor-specific bi-specific antibody efficacy.

Neshat SaffarzadehEmelie FoordEoghan O'LearyRand MahmounThomas Birkballe HansenVictor LevitskyThomas PoiretMichael Uhlin

Published in: Journal of translational medicine (2024)

Together, our data suggests that oncolytic adenoviruses encoding ICOSL may enhance functional activity of tumor-specific BsAbs thereby opening a novel avenue for clinical development in immunotherapeutics.

Keyphrases

poor prognosis
electronic health record
big data
binding protein
deep learning
artificial intelligence
data analysis
gene therapy