Mucosal circadian rhythm pathway genes altered by aging and periodontitis.
Jeffrey L EbersoleOctavio A GonzalezPublished in: PloS one (2022)
The chronic inflammation of periodontitis exhibits an alteration of the circadian rhythm pathway, predominantly via decreased gene expression. Thus, variation in disease expression and the underlying molecular mechanisms of disease may be altered due to changes in regulation of the circadian rhythm pathway functions.