A Higher Antibody Response Is Generated With a 6- to 7-Week (vs Standard) Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccine Dosing Interval.

Brian E GrunauMichael Asamoah-BoahengPascal M LavoieMohammad Ehsanul KarimTracy L KirkhamPaul A DemersVilte BarakauskasAna Citlali MarquezAgatha N JassemSheila F O'BrienSteven J DrewsScott HaigSheldon CheskesDavid M Goldfarb

Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2021)

The optimal dosing interval for severe acute respiratory syndrome coronavirus 2 vaccines remains controversial. In this prospective study, we compared serology results of paramedics vaccinated with mRNA vaccines at the recommended short (17-28 days) vs long (42-49 days) interval. We found that a long dosing interval resulted in higher spike, receptor binding domain, and spike N terminal domain antibody concentrations.

Keyphrases

respiratory syndrome coronavirus
sars cov
coronavirus disease
binding protein
randomized controlled trial
clinical trial
dna binding