Discovery of Targets for Immune-Metabolic Antitumor Drugs Identifies Estrogen-Related Receptor Alpha.

Avinash Das Sahu Xiao-Man Wang Phillip Munson Jan P G Klomp Xiaoqing Wang Shengqing Stan Gu Ya Han Gege Qian Phillip Nicol Zexian Zeng Chenfei Wang Collin J Tokheim Wubing Zhang Jingxin Fu Jin Wang Nishanth Ulhas Nair Joost A P Rens Meriem Bourajjaj Bas Jansen Inge Leenders Jaap Lemmers Mark Musters Sanne van Zanten Laura van Zelst Jenny Worthington Zhirui Hu Dejan Juric Clifford A Meyer Arthur Oubrie X Shirley Liu David E Fisher Keith T Flaherty

Published in: Cancer discovery (2023)

BipotentR presents resources for evaluating patient response and identifying targets for drugs that can kill tumors through multiple mechanisms concurrently. Inhibition of the topmost candidate target killed tumors by suppressing energy metabolism and effects on two immune mechanisms. This article is highlighted in the In This Issue feature, p. 517.

Keyphrases

small molecule
machine learning
case report

genome wide
drug induced
deep learning

high throughput
estrogen receptor

dna methylation
single cell