Fatal neuroinvasion of SARS-CoV-2 in K18-hACE2 mice is partially dependent on hACE2 expression.

Mariano CarossinoPaige MontanaroAoife O'ConnellDevin KenneyHans GertjeKyle A GroszSusanna A KurnickMarkus BosmannMohsan SaeedUdeni B R BalasuriyaFlorian DouamNicholas A Crossland

Published in: bioRxiv : the preprint server for biology (2021)

COVID-19 is a respiratory disease caused by SARS-CoV-2, a betacoronavirus. Here, we show that in a widely used transgenic mouse model of COVID-19, lethality is invariably associated with viral neuroinvasion and the ensuing neuronal disease, while lung inflammation remains moderate.

Keyphrases

sars cov
mouse model
respiratory syndrome coronavirus
poor prognosis
oxidative stress
coronavirus disease
high intensity
high fat diet induced
binding protein
skeletal muscle
brain injury