Combined effects of progesterone and SOCS3 DNA methylation on T2DM: a case-control study.
Lulu WangZhenxing MaoXiaotian LiuDandan WeiPengling LiuLuting NieKeliang FanNing KangYu SongQingqing XuJuan WangMian WangWei LiaoTao JingWenjie LiChongjian WangWenqian HuoPublished in: Clinical epigenetics (2021)
The independent and combined effects of progesterone and SOCS3 methylation on T2DM were found among men and postmenopausal women, suggesting that ensuring low levels of progesterone and high methylation of SOCS3 could reduce the prevalence of T2DM. Trial registration The Chinese Clinical Trial registration: The Henan Rural Cohort Study, ChiCTR-OOC-15006699. Registered 06 July 2015, http://www.chictr.org.cn/showproj.aspx?proj=11375.
Keyphrases
- postmenopausal women
- dna methylation
- clinical trial
- genome wide
- bone mineral density
- estrogen receptor
- phase ii
- study protocol
- phase iii
- glycemic control
- gene expression
- risk factors
- south africa
- open label
- lymph node metastasis
- type diabetes
- randomized controlled trial
- copy number
- adipose tissue
- double blind
- skeletal muscle