KDM1A genotyping and expression in 146 sporadic somatotroph pituitary adenomas.

Fanny Chasseloup Daniela RegazzoLucie ToscaAlexis ProustEmmanuelle KuhnMirella HageChristel JublancKarima MokhtariMattia Dalle NogareSerena AvalloneFilippo CeccatoGerard TachdjianSylvie SalenaveJacques YoungStephan GaillardFabrice ParkerAnne-Laure BochPhilippe ChansonJerome BouligandGianluca OcchiPeter Kamenicky

Published in: European journal of endocrinology (2024)

Unlike in GIP-dependent primary bilateral macronodular adrenal hyperplasia, KDM1A genetic variations are not the cause of GIPR expression in somatotroph pituitary adenomas. Recurrent KDM1A haploinsufficiency, more frequently observed in GIPR-expressing adenomas, could be responsible for decreased KDM1A function resulting in transcriptional derepression on the GIPR locus.

Keyphrases

poor prognosis
genome wide
binding protein
growth hormone
long non coding rna
transcription factor
late onset
high throughput
dna methylation
case report
copy number
amyotrophic lateral sclerosis
wild type