Hesperetin Induces Autophagy and Delayed Apoptosis by Modulating the AMPK/Akt/mTOR Pathway in Human Leukemia Cells In Vitro.
Ching-Yeh LinYa-Hui ChenYing-Chih HuangPublished in: Current issues in molecular biology (2023)
Hesperetin promoted cell death in the human leukemic cell line U937 by inducing a low degree of slight apoptosis, cell cycle arrest, and autophagy. It is therefore a potential adjuvant to antileukemia therapy and may be combined with other chemotherapeutic drugs to reduce chemoresistance and side effects.
Keyphrases
- cell cycle arrest
- cell death
- pi k akt
- signaling pathway
- endothelial cells
- acute myeloid leukemia
- cell proliferation
- induced pluripotent stem cells
- pluripotent stem cells
- endoplasmic reticulum stress
- early stage
- bone marrow
- skeletal muscle
- oxidative stress
- induced apoptosis
- risk assessment
- climate change
- human health
- drug induced