Examining what factors mediate treatment effect in chronic low back pain: A mediation analysis of a Cognitive Functional Therapy clinical trial.
Aoife O'NeillKieran O'SullivanPeter O'SullivanHelen PurtillMary O'KeeffePublished in: European journal of pain (London, England) (2020)
An exploration of seven potential mediators was undertaken to determine the effect of Cognitive Functional Therapy (CFT) on disability and pain intensity in individuals with chronic low back pain compared to a group exercise and education intervention. CFT improved pain self-efficacy, which was associated with disability and pain outcomes. CFT did not improve the other six potential mediators (stress, fear of physical activity, coping, depression, anxiety and sleep) and these were not associated with disability or pain. The proportion of missing data in this study is substantial and these findings should be considered hypothesis-generating only.
Keyphrases
- chronic pain
- physical activity
- pain management
- neuropathic pain
- clinical trial
- multiple sclerosis
- sleep quality
- depressive symptoms
- healthcare
- high intensity
- social support
- spinal cord injury
- electronic health record
- open label
- insulin resistance
- postoperative pain
- phase ii
- combination therapy
- heat stress
- weight loss
- replacement therapy