Protective effect of hesperidin in Poloxamer-407 induced hyperlipidemic experimental rats.
Raushan KumarFarhan AkhtarSyed Ibrahim RizviPublished in: Biologia futura (2021)
Hyperlipidemia is one of the leading causes of, atherosclerosis, and cardiovascular disease. In this study, we evaluated the protective role of hesperidin (HES) against lipidemic stress in a hyperlipidemic model of rats. We developed a hyperlipidemic model of the rat through an i.p dose of poloxamer-407, 0.5 g/kg body weight for 3 alternative days in a week for 30 days and rats were supplemented with HES orally (100 mg/kg body weight) once daily. Bodyweight, fasting glucose, insulin, HOMA-IR index, triglyceride, cholesterol, ROS, FRAP, GSH, PMRS, AGE, MDA, PCO, AOPP, PON-1, TNF-α and IL-6, SGPT and SGOT were estimated in blood and plasma, and histopathology was done in liver tissue. Our data show that oxidative stress, inflammatory markers were increased in the P-407 treated group. Liver tissue histology also changes in the hyperlipidemic groups of rats.HES supplementation protects against P-407 induced alterations and maintains the redox homeostasis. Our results provide evidence that HES protects against lipidemic stress and redox imbalance induced by P-407 in rats.
Keyphrases
- body weight
- cardiovascular disease
- oxidative stress
- type diabetes
- diabetic rats
- rheumatoid arthritis
- dna damage
- randomized controlled trial
- high glucose
- cell death
- adipose tissue
- endothelial cells
- machine learning
- metabolic syndrome
- cell proliferation
- ischemia reperfusion injury
- cardiovascular events
- newly diagnosed
- heat shock protein
- weight loss
- induced apoptosis
- low density lipoprotein
- heat shock
- data analysis