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Real-world efficacy of single-agent belantamab mafodotin in relapsed systemic AL amyloidosis.

Jahanzaib KhwajaJoshua BomsztykMaria AttaCeri A BygraveAdam ForbesSenthil DurairajSavio FernandesJames TaylorPamela PatersonGillian BreartonCharles CrawleyOonagh SheehyRachel BrownRichard SoutarMamta GargAndrzej RydzewskiKrzysztof JamroziakShameem MahmoodAshutosh D Wechalekar
Published in: British journal of haematology (2024)
Systemic light chain (AL) amyloidosis is a relapsing plasma cell disorder. Therapy is limited, particularly for triple-class refractory disease. We report the use of belantamab mafodotin, a BCMA-directed drug-antibody conjugate, for relapsed AL amyloidosis, including patients traditionally excluded from clinical trials. Thirty-one patients were reviewed, with a median of three prior lines of therapy. The median follow-up was 12 months (95% CI 4-19), and a median of five doses were delivered. The best haematological overall response rate was 71%, and the complete/very good partial response was 58%. Sixty-eight percent had keratopathy and improved in all. Belantamab mafodotin has high efficacy and good tolerability in patients with relapsed AL amyloidosis.
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