Apalutamide and autophagy inhibition in a xenograft mouse model of human prostate cancer.
Daniel EberliBenedikt KranzbühlerLukas PrauseValentin BaumgartnerSheryl PredaRosa SousaFabienne LehnerSouzan SalemiPublished in: Journal of cancer research and clinical oncology (2022)
These data demonstrate that a treatment with APA + Chl leads to reduced autophagy levels and to tumor suppression compared to the APA monotherapy. Hence, the increased antitumor effect of APA in combination with autophagy inhibitors might provide a new therapeutic approach potentially translatable to patients.
Keyphrases
- prostate cancer
- cell death
- endoplasmic reticulum stress
- mouse model
- signaling pathway
- oxidative stress
- end stage renal disease
- endothelial cells
- ejection fraction
- newly diagnosed
- chronic kidney disease
- combination therapy
- prognostic factors
- peritoneal dialysis
- radical prostatectomy
- randomized controlled trial
- electronic health record
- clinical trial
- machine learning
- open label
- induced pluripotent stem cells
- smoking cessation