Impact of Hematopoietic Cell Transplantation on Myocardial Fibrosis in Young Patients with Sickle Cell Disease.

Akshay Sharma Subodh R Selukar Yu Bi Anthony Merlocco Cara E MorinChris GoodeParul RaiJeffrey Allen TowbinJane Silva Hankins Stephen Gottschalk Brandon M Triplett Jason Nathaniel Johnson

Published in: Blood (2024)

Serial cardiovascular magnetic resonance evaluation of children and young adults with sickle cell disease (SCD) who underwent hematopoietic cell transplantation (HCT) showed that the mean ECV, representing diffuse myocardial fibrosis, decreased by 3.4% from the baseline to 12-months post HCT. (NCT04362293).

Keyphrases

sickle cell disease
young adults
magnetic resonance
left ventricular
cell cycle arrest
low grade
liver fibrosis
childhood cancer
contrast enhanced
computed tomography