Cardiac Magnetic Resonance Studies in a Large Animal Model That Simulates the Cardiac Abnormalities of Human Septic Shock.
Verity J FordWillard N ApplefeldJeffrey WangJunfeng SunSteven B SolomonStanislav SidenkoJing FengCynthia SheffieldHarvey G KleinZu-Xi YuParizad Torabi-PariziRobert L DannerVandana SachdevMichael A SolomonMarcus Y ChenCharles NatansonPublished in: Journal of the American Heart Association (2024)
The cardiac dysfunction of sepsis is associated with wall edema. In nonsurvivors, at 0 to 24 hours, sepsis induces a more severe diastolic dysfunction, further decreasing chamber size. The loss of left ventricular mass with wall thinning in septic survivors may, in part, explain the EDV increases from 24 to 48 hours because of a potentially reparative process removing damaged wall tissue. Septic cardiomyopathy is most consistent with a nonocclusive microvascular injury resulting in edema causing reversible systolic and diastolic dysfunction with more severe diastolic dysfunction being associated with a decreased EDV and death.
Keyphrases
- left ventricular
- septic shock
- heart failure
- acute kidney injury
- hypertrophic cardiomyopathy
- magnetic resonance
- cardiac resynchronization therapy
- acute myocardial infarction
- oxidative stress
- left atrial
- aortic stenosis
- mitral valve
- blood pressure
- intensive care unit
- magnetic resonance imaging
- young adults
- computed tomography
- transcatheter aortic valve replacement
- contrast enhanced
- ejection fraction
- pluripotent stem cells