Morbid Obesity in Women Is Associated with an Altered Intestinal Expression of Genes Related to Cancer Risk and Immune, Defensive, and Antimicrobial Response.
Ailec Ho-PlágaroCristina Rodríguez-DíazConcepción Santiago-FernándezCarlos Lopez-GomezSara García-SerranoFlores Martín-ReyesFrancisca Rodríguez-PachecoAlberto Rodríguez-CañeteGuillermo Alcaín-MartínezLuis Vázquez-PedreñoSergio ValdésLourdes Garrido-SánchezEduardo Garcia-FuentesPublished in: Biomedicines (2022)
Regardless of the degree of IR, morbid obesity is associated with an altered expression of genes related to intestinal defenses, antimicrobial and immune responses, and gastrointestinal cancer. Our data also suggest a deficient duodenal immune and antimicrobial response in women with high IR.
Keyphrases
- staphylococcus aureus
- poor prognosis
- weight loss
- insulin resistance
- metabolic syndrome
- bariatric surgery
- immune response
- type diabetes
- genome wide
- weight gain
- high fat diet induced
- polycystic ovary syndrome
- papillary thyroid
- binding protein
- genome wide identification
- bioinformatics analysis
- squamous cell carcinoma
- pregnant women
- big data
- obese patients
- gene expression
- machine learning
- pregnancy outcomes
- genome wide analysis
- artificial intelligence
- inflammatory response
- dendritic cells
- childhood cancer