Clonal Proliferation Within Smooth Muscle Cells in Unstable Human Atherosclerotic Lesions.
Kenji KawaiAtsushi SakamotoMichal MokrySaikat Kumar B GhoshRika KawakamiWeili XuLiang GuoDaniela T FullerTakamasa TanakaPalak ShahAnne CornelissenYu SatoMasayuki MoriTakao KonishiAimee E VozenilekRoma DhingraRenu VirmaniGerard PasterkampAloke V FinnPublished in: Arteriosclerosis, thrombosis, and vascular biology (2023)
Our novel approach to examine clonality suggests atherosclerosis is primarily a disease of polyclonally and to a lesser extent clonally expanded SMCs and may have implications for the development of antiatherosclerotic therapies.