Androgen and oestrogen receptor co-expression determines the efficacy of hormone receptor-mediated radiosensitisation in breast cancer.

Anna R MichmerhuizenLynn M LernerConnor WardAndrea M PeschAmanda ZhangRachel SchwartzKari Wilder-RomansJoel R EisnerJames M RaeLori J PierceCorey W Speers

Published in: British journal of cancer (2022)

While radiosensitising in AR + TNBC, AR inhibition does not modulate radiation sensitivity in AR+/ER+ breast cancer. The efficacy of ER antagonists in combination with RT may also be dependent on AR expression.

Keyphrases

poor prognosis
binding protein
endoplasmic reticulum
estrogen receptor
breast cancer cells
radiation induced
childhood cancer