STING-mediated IL-6 Inhibits OATP1B1 Expression via the TCF4 Signaling Pathway in Cholestasis.

Yan GuoHongjia ZhangNan ZhaoYing PengDongya ShenYubin ChenXiaoxun ZhangCan-E Tang Jin Chai

Published in: Journal of clinical and translational hepatology (2024)

STING-mediated IL-6 up-regulation may inhibit OATP1B1, leading to reduced transport of bile acids and bilirubin by OATP1B1. This may contribute to altered pharmacokinetics in patients with diseases associated with increased IL-6 production.

Keyphrases

signaling pathway
poor prognosis
epithelial mesenchymal transition
oxidative stress
cell proliferation
induced apoptosis