Combined prenatal Lactobacillus reuteri and ω-3 supplementation synergistically modulates DNA methylation in neonatal T helper cells.
Johanna HuomanDavid Martínez-EnguitaElin OlssonJan ErnerudhLennart NilssonKarel DuchénMika GustafssonMaria C JenmalmPublished in: Clinical epigenetics (2021)
Prenatal L. reuteri and/or ω-3 fatty acid treatment results in hypermethylation and affects immune- and allergy-related pathways in neonatal T helper cells, with potentially synergistic effects between the interventions and relevance for allergic disease. Further studies need to address these findings on a transcriptional level, and whether the results associate to allergy development in the children. Understanding the role of DNA methylation in regulating effects of perinatal probiotic and ω-3 interventions may provide essential knowledge in the development of efficacious allergy preventive strategies. Trial registration ClinicalTrials.gov, ClinicalTrials.gov-ID: NCT01542970. Registered 27th of February 2012-Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT01542970 .
Keyphrases
- dna methylation
- induced apoptosis
- pregnant women
- gene expression
- cell cycle arrest
- fatty acid
- atopic dermatitis
- regulatory t cells
- physical activity
- genome wide
- healthcare
- dendritic cells
- clinical trial
- endoplasmic reticulum stress
- computed tomography
- study protocol
- transcription factor
- signaling pathway
- infectious diseases
- oxidative stress
- cell death
- magnetic resonance imaging
- cancer therapy
- drug delivery
- positron emission tomography
- combination therapy
- phase iii
- phase ii
- heat stress
- heat shock
- smoking cessation