The mammalian target of rapamycin protein expression in human granulosa cell tumors
Onur GuralpTugan BeşeGamze BildikFuat DemirkiranÜmit İnceEduard MalikMacit ArvasOzgur OktemPublished in: Journal of the Turkish German Gynecological Association (2018)
mTOR expression is observed in various degrees in 90%, and p-mTOR expression is observed in only 10% of patients with granulosa cell ovarian carcinoma. Rapamycin caused a dose-dependent growth arrest and apoptosis in COV434 mitotic granulosa cells.
Keyphrases
- poor prognosis
- cell cycle arrest
- polycystic ovary syndrome
- single cell
- induced apoptosis
- cell therapy
- endothelial cells
- cell proliferation
- cell cycle
- oxidative stress
- endoplasmic reticulum stress
- cell death
- sars cov
- stem cells
- metabolic syndrome
- pi k akt
- mesenchymal stem cells
- signaling pathway
- induced pluripotent stem cells