MicroRNA-mediated Regulation of Mucin-type O-glycosylation Pathway: A Putative Mechanism of Salivary Gland Dysfunction in Sjögren Syndrome.

Alessia Gallo Serena Vella Fabio Tuzzolino Nicola Cuscino Antonella Cecchettini Francesco Ferro Marta Mosca Ilias AlevizosStefano BombardieriPier Giulio Conaldi Chiara Baldini

Published in: The Journal of rheumatology (2019)

Collectively, our data suggest that the expression of different predicted miRNA-target genes in the mucin type O-glycan biosynthesis pathway is altered in pSS patients with low salivary flow and that the miRNA expression profile could influence the glycosidase expression levels and consequently the rheology in pSS.

Keyphrases

poor prognosis
binding protein
oxidative stress
genome wide
long non coding rna
gene expression
machine learning
genome wide identification