CRISPulator: a discrete simulation tool for pooled genetic screens.

Published in: BMC bioinformatics (2017)

CRISPulator facilitates the design of pooled genetic screens by enabling the exploration of a large space of experimental parameters in silico, rather than through costly experimental trial and error. We illustrate its power by deriving non-obvious rules for optimal screen design.

Keyphrases

genome wide
high throughput
phase iii
dna methylation
copy number
clinical trial
phase ii
open label
gene expression