The Effect of Resveratrol on Cell Viability in the Burkitt's Lymphoma Cell Line Ramos.
Paola JaraJohana SpiesConstanza CárcamoYennyfer ArancibiaGabriela VargasCarolina MartinMónica SalasCarola OtthAngara ZambranoPublished in: Molecules (Basel, Switzerland) (2017)
Resveratrol is a polyphenolic natural compound produced by a variety of crops. Currently, resveratrol is considered a multi-target anti-cancer agent with pleiotropic activity, including the ability to prevent the proliferation of malignant cells by inhibiting angiogenesis and curtailing invasive and metastatic factors in many cancer models. However, the molecular mechanisms mediating resveratrol-specific effects on lymphoma cells remain unknown. To begin tackling this question, we treated the Burkitt's lymphoma cell line Ramos with resveratrol and assessed cell survival and gene expression. Our results suggest that resveratrol shows a significant anti-proliferative and pro-apoptotic activity on Ramos cells, inducing the DNA damage response, DNA repairing, and modulating the expression of several genes that regulate the apoptotic process and their proliferative activity.
Keyphrases
- induced apoptosis
- cell cycle arrest
- gene expression
- cell death
- signaling pathway
- dna damage response
- diffuse large b cell lymphoma
- small cell lung cancer
- squamous cell carcinoma
- oxidative stress
- poor prognosis
- dna methylation
- genome wide
- endoplasmic reticulum stress
- dna repair
- papillary thyroid
- cell proliferation
- transcription factor
- circulating tumor
- pi k akt
- lymph node metastasis
- binding protein
- nucleic acid