Body Mass Index and Allostatic Load are Directly Associated with Longitudinal Increase in Plasma Neurofilament Light Among Urban Middle-aged Adults.

Cardiometabolic risk factors, particularly elevated HbA1c, should be screened and targeted for neurodegenerative disease, pending comparable longitudinal studies. Other studies examining the clinical utility of plasma NfL as a neurodegeneration marker should account for confounding effects of BMI and AL.