The effect of chronic intermittent hypoxia in cardiovascular gene expression is modulated by age in a mice model of sleep apnea.
Anabel Lourdes Castro-GrattoniMonique Suarez-GironIvan BenitezLourdes TecchiaMarta TorresIsaac AlmendrosRamon FarreAdriano TargaJosep M MontserratMireia DalmasesFerran BarbéDavid GozalManuel Sánchez-de-la-TorrePublished in: Sleep (2021)
CIH effect in gene expression is organ-dependent, and is modulated by age. CIH increased transcriptional expression of genes involved in cardioprotection and cell survival in young, but not in old mice. In aortic tissue, CIH reduced gene expression related to an antioxidant response in both young and old mice, suggesting vascular oxidative stress and a proaging process.
Keyphrases
- gene expression
- oxidative stress
- sleep apnea
- dna methylation
- high fat diet induced
- poor prognosis
- dna damage
- obstructive sleep apnea
- endothelial cells
- aortic valve
- heart failure
- high intensity
- positive airway pressure
- ischemia reperfusion injury
- long non coding rna
- left ventricular
- heat shock
- skeletal muscle
- signaling pathway
- diabetic rats