Evaluating the Contribution of Cell Type-Specific Alternative Splicing to Variation in Lipid Levels.

Katerina A B GawronskiWilliam P BoneYoSon ParkEvanthia E PashosBrandon M WenzMax F DudekXiao Wang Wenli Yang Daniel James Rader Kiran MusunuruBenjamin F VoightChristopher D Brown

Published in: Circulation. Genomic and precision medicine (2023)

These results provide an important foundation for future efforts that use iPSC and iPSC-derived cells to evaluate genetic mechanisms influencing both cardiovascular disease risk and complex traits in general.

Keyphrases

cardiovascular disease
induced apoptosis
genome wide
cell cycle arrest
induced pluripotent stem cells
type diabetes
oxidative stress
current status
quality improvement
endoplasmic reticulum stress
fatty acid
copy number
cardiovascular events
signaling pathway
coronary artery disease
gene expression
pi k akt