Evaluation of p53 and Its Target Gene Expression as Potential Biomarkers of Cholangiocarcinoma in Thai Patients.

Janpen PuetkasichonpasuthaNisana NamwatPrakasit Sa-NgiamwiboolAttapol TitapunTuangporn Suthiphongchai

Published in: Asian Pacific journal of cancer prevention : APJCP (2020)

Our results demonstrated statistically significant association between down-regulation of WIP1 with non-papillary type and with high p53 protein level, and PAI-1 was down-regulated in almost all CCA. Therefore, expression level of WIP1 and PAI-1 may be useful for predicting p53 functional status and as a potential diagnostic marker of CCA, respectively.

Keyphrases

gene expression
end stage renal disease
ejection fraction
chronic kidney disease
poor prognosis
dna methylation
prognostic factors
binding protein
patient reported outcomes
protein protein
small molecule