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Generalizability of randomized trial results to target populations: Design and analysis possibilities.

Elizabeth A StuartBenjamin AckermanDaniel Westreich
Published in: Research on social work practice (2017)
Randomized trials play an important role in estimating the effect of a policy or social work program in a given population. While most trial designs benefit from strong internal validity, they often lack external validity, or generalizability, to the target population of interest. In other words, one can obtain an unbiased estimate of the study sample average treatment effect (SATE) from a randomized trial; however, this estimate may not equal the target population average treatment effect (TATE) if the study sample is not fully representative of the target population. This paper provides an overview of existing strategies to assess and improve upon the generalizability of randomized trials, both through statistical methods and study design, as well as recommendations on how to implement these ideas in social work research.
Keyphrases
  • healthcare
  • mental health
  • public health
  • clinical trial
  • randomized controlled trial
  • study protocol
  • quality improvement
  • clinical practice