Combination of curcumin and piperine synergistically improves pain-like behaviors in mouse models of pain with no potential CNS side effects.

Pawana BoonruengPeththa Wadu Dasuni Wasananull HasriadiOpa VajraguptaPornchai RojsitthisakPasarapa Towiwat

Published in: Chinese medicine (2022)

Overall, the present study demonstrates strong antinociceptive synergism between curcumin and piperine in mouse models with no potential CNS side effects, suggesting its possible use in clinical trials.

Keyphrases

mouse model
chronic pain
clinical trial
pain management
neuropathic pain
blood brain barrier
human health
randomized controlled trial
spinal cord
anti inflammatory