Adipocyte-Derived Serum Amyloid A Promotes Angiotensin II-Induced Abdominal Aortic Aneurysms in Obese C57BL/6J Mice.
Preetha ShridasAiling JiAndrea C TrumbauerVictoria P NoffsingerSteve W LeungAdam J DuganSean E ThatcherLisa A CassisFrederick C de BeerNancy R WebbLisa R TannockPublished in: Arteriosclerosis, thrombosis, and vascular biology (2022)
We demonstrate for the first time that SAA deficiency protects obese C57BL/6J mice from Ang II-induced AAA. SAA expression only in adipocytes is sufficient to cause AAA in obese mice infused with Ang II.
Keyphrases
- angiotensin ii
- adipose tissue
- angiotensin converting enzyme
- high glucose
- vascular smooth muscle cells
- high fat diet induced
- abdominal aortic
- metabolic syndrome
- diabetic rats
- weight loss
- insulin resistance
- type diabetes
- drug induced
- endothelial cells
- obese patients
- fatty acid
- oxidative stress
- bariatric surgery
- skeletal muscle
- replacement therapy
- long non coding rna
- wild type
- smoking cessation