Prediction of olanzapine exposure in individual patients using physiologically based pharmacokinetic modelling and simulation.

Thomas M PolasekGeoffrey T TuckerMichael J SorichMichael D WieseTitus MohanAmin Rostami-HodjeganPorntipa KorprasertthawornVidya Perera Andrew Rowland

Published in: British journal of clinical pharmacology (2018)

Olanzapine exposure in individual patients was predicted using PBPK M&S. Repurposing of available PBPK M&S platforms is an option for model-informed precision dosing and requires further study to examine clinical potential.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
patient reported