The Genomics of Colorectal Cancer in Populations with African and European Ancestry.

Parvathi A Myer Jessica K Lee Russell W MadisonKith PradhanJustin Y NewbergCarmen R IsasiSamuel J Klempner Garrett M Frampton Jeffery S RossJeffrey M VenstromAlexa B SchrockSudipto DasLeonard AugenlichtAmit VermaJohn M GreallySrilakshmi M RajSanjay Goel Siraj M Ali

Published in: Cancer discovery (2022)

KRAS (particularly KRASG12D/G13), APC, and PIK3CA were more frequently altered in AFR who had a lower frequency of MSI-H tumors. There were no differences in actionable kinase driver alterations. In young-onset colorectal cancer, both ancestries had a similar frequency of MSI-H/TMB-H tumors, but strikingly different trends in APC. See related commentary by Eng and Holowatyj, p. 1187. This article is highlighted in the In This Issue feature, p. 1171.

Keyphrases

protein kinase
machine learning
deep learning
wild type
genetic diversity