Replicated evidence that endophenotypic expression of schizophrenia polygenic risk is greater in healthy siblings of patients compared to controls, suggesting gene-environment interaction. The EUGEI study.
Jim Van OsLotta-Katrin PriesPhilippe DelespaulGunter KenisJurjen J LuykxBochao D LinAlexander L RichardsBerna AkdedeTolga BinbayVesile AltınyazarBerna YalınçetinGüvem Gümüş-AkayBurçin CihanHaldun SoygürHalis UlaşEylem Şahin CankurtaranSemra Ulusoy KaymakMarina M MihaljevicSanja Andric PetrovicTijana MirjanicMiguel BernardoBibiana CabreraJulio BobesPilar A SaizMaría Paz García-PortillaJulio SanjuanEduardo J AguilarJosé Luis SantosEstela Jiménez-LópezManuel ArrojoAngel CarracedoGonzalo LópezJavier González-PeñasMara ParelladaNadja P MaricCem AtbaşoğluAlp UcokKöksal AlptekinMeram Can Sakanull nullCelso ArangoMichael O'DonovanBart P F RuttenSinan GuloksuzPublished in: Psychological medicine (2019)
The degree of endophenotypic expression of schizophrenia polygenic risk depends on having a sibling with psychotic disorder, suggestive of underlying gene-environment interaction. Cognitive biases may better index genetic risk of disorder than traditional measures of neurocognition, which instead may reflect the population distribution of cognitive ability impacting the prognosis of psychotic disorder.