Long noncoding RNA SNHG16 regulates TLR4-mediated autophagy and NETosis formation in alveolar hemorrhage associated with systemic lupus erythematosus.
Yu-Tung HsiehYi-Cheng ChenYu-Chi ChouPin-Yu KuoYi-Ting YenHung-Wen TsaiChrong-Reen WangPublished in: Journal of biomedical science (2023)
Our results demonstrate that lncRNA SNHG16 regulates TLR4-mediated autophagy and NETosis formation in the human and mouse AH lungs, and provide a therapeutic potential of intra-pulmonary delivery of shRNA targeting SNHG16 in this SLE-related lethal manifestation.
Keyphrases
- long noncoding rna
- systemic lupus erythematosus
- poor prognosis
- toll like receptor
- cell death
- disease activity
- endoplasmic reticulum stress
- inflammatory response
- immune response
- signaling pathway
- endothelial cells
- long non coding rna
- oxidative stress
- pulmonary hypertension
- nuclear factor
- cancer therapy
- induced pluripotent stem cells