The nutrient-sensing Rag-GTPase complex in B cells controls humoral immunity via TFEB/TFE3-dependent mitochondrial fitness.

Xingxing ZhuYue WuYanfeng LiXian ZhouJens O WatzlawikYin Maggie ChenAriel L RaybuckDaniel BilladeauVirginia ShapiroWolfdieter SpringerJie SunMark R BoothbyHu Zeng

Published in: bioRxiv : the preprint server for biology (2024)

Rag-GTPases restrain TFEB/TFE3 to prevent abnormal mitophagy, maintain mitochondrial fitness, and support B cell development, Peyer's patch germinal center formation, and T-independent humoral immunity.

Keyphrases

immune response
oxidative stress
body composition
physical activity
nlrp inflammasome