ROS-responsive curcumin-encapsulated nanoparticles for AKI therapy via promoting lipid degradation in renal tubules.
Honglei GuoTianyu LanXin LuKedui GengXiangchun ShenHuijuan MaoQianqian GuoPublished in: Journal of materials chemistry. B (2024)
Lipid accumulation is a factor contributing to the pathogenesis of acute kidney injury (AKI), yet there are currently no approved pharmacotherapies aside from adjuvant therapy. A developed reactive oxygen species (ROS)-responsive drug delivery system (NPS BG @Cur) was developed to deliver the autophagy activator curcumin (Cur) in order to alleviate AKI by activating autophagy and promoting lipid droplet degradation. The nanoparticles were shown to be ROS-responsive in the H 2 O 2 medium and demonstrate ROS-responsive uptake in palmitate (PA)-induced oxidative stress-damaged cells. NPS BG @Cur was found to effectively inhibit lipid accumulation by autophagosome transport in kidney tubular cells. Additionally, in a mouse AKI model, NPS BG @Cur was observed to significantly ameliorate renal damage by activating autophagy flux and improving lipid transport. These results suggest that the ROS-responsive drug delivery system augmented the therapeutic effect of Cur on AKI by improving lipid metabolism through autophagy activation. Therefore, targeting lipid metabolism with NPS BG @Cur may be a promising AKI treatment strategy.
Keyphrases
- acute kidney injury
- cell death
- cell cycle arrest
- reactive oxygen species
- induced apoptosis
- cancer therapy
- cardiac surgery
- signaling pathway
- endoplasmic reticulum stress
- oxidative stress
- dna damage
- fatty acid
- drug delivery
- pi k akt
- single cell
- oxide nanoparticles
- mesenchymal stem cells
- cell proliferation
- nuclear factor
- inflammatory response
- combination therapy
- drug administration