Nebulised mesenchymal stem cell derived extracellular vesicles ameliorate E. coli induced pneumonia in a rodent model.

Hector GonzalezSean McCarthyClaire MastersonDeclan ByrnesIgnacio SallentEmma HoranStephen J EllimanGabriele VellaAdriele P MelloJohnatas D SilvaAnna D KrasnodembskayaRonan MacLoughlinJohn G LaffeyDaniel O'Toole

Published in: Stem cell research & therapy (2023)

MSC-EVs given IV attenuated LPS-induced lung injury, and nebulisation of MSC-EVs did not affect their capacity to attenuate lung injury caused by E. coli pneumonia, as evidenced by reduction in bacterial load and improved lung physiology.

Keyphrases

lps induced
inflammatory response
escherichia coli
high glucose
stem cells
diabetic rats
bone marrow
respiratory failure
community acquired pneumonia
oxidative stress
endothelial cells
stress induced