Whole genome sequences of multi-drug resistant Escherichia coli isolated in a Pastoralist Community of Western Uganda: Phylogenomic changes, virulence and resistant genes.
Jacob Stanley IramiotHenry KajumbulaJoel BaziraEtienne Pierre de VilliersBenon B AsiimwePublished in: PloS one (2020)
From the analysis of the core genome and phenotypic resistance, this study has demonstrated that the E. coli of human origin and those of cattle origin may have a common ancestry. Limited sharing of virulence genes presents a challenge to the notion that AMR in humans is as a result of antibiotic use in the farm and distorts the picture of the directionality of transmission of AMR at a human-animal interface and presents a task of exploring alternative routes of transmission of AMR.
Keyphrases
- escherichia coli
- drug resistant
- endothelial cells
- antimicrobial resistance
- genome wide
- multidrug resistant
- biofilm formation
- pseudomonas aeruginosa
- staphylococcus aureus
- induced pluripotent stem cells
- acinetobacter baumannii
- healthcare
- pluripotent stem cells
- mental health
- south africa
- social media
- klebsiella pneumoniae
- bioinformatics analysis
- health information
- genome wide identification
- gene expression
- candida albicans
- genome wide association study