Thanksgiving to Yeast, the HMGB Proteins History from Yeast to Cancer.
Mónica Lamas-MaceirasÁngel Vizoso-VázquezAida Barreiro-AlonsoMaría Cámara-QuílezMaría Esperanza CerdánPublished in: Microorganisms (2023)
Yeasts have been a part of human life since ancient times in the fermentation of many natural products used for food. In addition, in the 20th century, they became powerful tools to elucidate the functions of eukaryotic cells as soon as the techniques of molecular biology developed. Our molecular understandings of metabolism, cellular transport, DNA repair, gene expression and regulation, and the cell division cycle have all been obtained through biochemistry and genetic analysis using different yeasts. In this review, we summarize the role that yeasts have had in biological discoveries, the use of yeasts as biological tools, as well as past and on-going research projects on HMGB proteins along the way from yeast to cancer.
Keyphrases
- saccharomyces cerevisiae
- dna repair
- gene expression
- papillary thyroid
- dna damage
- endothelial cells
- squamous cell
- induced apoptosis
- dna methylation
- young adults
- cell therapy
- genome wide
- stem cells
- dna damage response
- childhood cancer
- pluripotent stem cells
- climate change
- lymph node metastasis
- mesenchymal stem cells
- bone marrow
- cell cycle arrest
- oxidative stress
- pi k akt