Measuring the differential expression of the major hypermethylated tumor suppressor genes in tissues of primary hepatocellular carcinoma.

Khalda Sayed AmrWafaa Mohamed EzzatAhmed Ibrahim SalehAhmed HeibaHend AminRefaat Refaat KamelNoha EltaweelHoda HeneryAmr OmaiaReham Ibrahim SiddikYasser Abdelghany Abdelazeem Elhosary

Published in: Journal, genetic engineering & biotechnology (2024)

Expression of the selected hypermethylated genes (SOCS1, APC, Gadd45b, CDKN1B, P15, PAX6, STAT1 and MSH2) in HCC tissue samples was lower than adjacent tissue. Their role should be further studied to solve the mystery that surrounds the pathogenesis of HCC.

Keyphrases

genome wide
poor prognosis
genome wide identification
bioinformatics analysis
cell proliferation
genome wide analysis
binding protein
long non coding rna
solid state