MCRS1 Expression Regulates Tumor Activity and Affects Survival Probability of Patients with Gastric Cancer.
Liang-Han WangChih-Chun ChangChiao-Yin ChengYao-Jen LiangDee PeiJen-Tang SunYen-Lin ChenPublished in: Diagnostics (Basel, Switzerland) (2022)
Gastric cancer is the fifth most common cancer worldwide and the third most common cause of cancer-related deaths. Surgery remains the first-choice treatment. Chemotherapy is considered in the middle and advanced stages, but has limited success. Microspherule protein 1 (MCRS1, also known as MSP58) is a protein originally identified in the nucleus and cytoplasm that is involved in the cell cycle. High expression of MCRS1 increases tumor growth, invasiveness, and metastasis. The mechanistic relationships between MCSR1 and proliferation, apoptosis, angiogenesis, and epithelial-mesenchymal transition (EMT) remain to be elucidated. We clarified these relationships using immunostaining of tumor tissues and normal tissues from patients with gastric cancer. High MCRS1 expression in gastric cancer positively correlated with Ki-67, Caspase3, CD31, Fibronectin, pAKT, and pAMPK. The hazard ratio of high MCRS1 expression was 2.44 times that of low MCRS1 expression, negatively impacting patient survival.
Keyphrases
- poor prognosis
- epithelial mesenchymal transition
- cell cycle
- binding protein
- cell death
- cell proliferation
- minimally invasive
- long non coding rna
- endoplasmic reticulum stress
- endothelial cells
- squamous cell carcinoma
- atrial fibrillation
- amino acid
- free survival
- rectal cancer
- decision making
- transforming growth factor
- pi k akt
- combination therapy
- plasmodium falciparum
- nk cells
- surgical site infection