Safety and efficacy of ripasudil eye drops in preterm infants with retinopathy of prematurity: phase 1/2, open label, single-arm trial.

Mitsuru ArimaHirosuke InoueAkiko MisumiShoko TsukamotoItsuka MatsushitaShunsuke ArakiManami OhtaKazumasa TakahashiMiyuki ImazatoTomoko GotoYoshinori AokiKoshiro TagawaMasayuki HiroseYuito FujitaNoriko YoshidaShintaro NakaoHiroyuki KondoKoichi KusuharaKazuhiro KimuraShunji HasegawaYasuhiro IkedaYuki KodamaHiroshi MoritakeMasayuki OchiaiShouichi OhgaJunji KishimotoKoji TodakaIchiro IeiriKoh-Hei Sonoda

Published in: Japanese journal of ophthalmology (2024)

Ripasudil was safe and inhibited/delayed type 1 ROP progression, especially in infants with short GA.

Keyphrases

preterm infants
open label
phase iii
phase ii
study protocol
pet ct
clinical trial
low birth weight
phase ii study
randomized controlled trial
double blind
placebo controlled
squamous cell carcinoma
radiation therapy
preterm birth