Optimization of coronary sinus lead placement targeted to the longest right-to-left delay in patients undergoing cardiac resynchronization therapy: The Optimal Pacing SITE 2 (OPSITE 2) acute study and protocol.
Daniele OddoneDiana SolariRené NangahGiuseppe ArenaRoberto MuredduDavide GiorgiNadir SittaNicola BottoniGaetano SenatoreMarzia GiaccardiMassimo GiammariaSakis ThemistoclakisMattia LaffiEliana CipollaFabio Di LorenzoRomina CarpiMichele BrignolePublished in: Pacing and clinical electrophysiology : PACE (2017)
We showed that RLD can be used to guide lead placement at the time of CRT implantation and that it is correlated with BIV-QRS width, an indirect predictor of clinical outcome. Based on these findings we started the prospective, multicenter Optimal Pacing SITE 2 (OPSITE 2) trial with the objective to demonstrate a relationship between RLD and clinical outcomes assessed as death, hospitalization for heart failure, New York Heart Association class, and clinical composite score. The protocol is provided.
Keyphrases
- cardiac resynchronization therapy
- heart failure
- left ventricular
- patients undergoing
- randomized controlled trial
- liver failure
- coronary artery
- coronary artery disease
- study protocol
- ultrasound guided
- acute heart failure
- aortic stenosis
- clinical trial
- respiratory failure
- phase iii
- drug induced
- intensive care unit
- aortic dissection
- open label
- aortic valve