Effector and regulatory dendritic cells display distinct patterns of miRNA expression.

Vincent LombardiSonia LuceHélène MoussuLise MorizurClaire GueguenCatherine NeukirchSylvie Chollet-MartinLaurent MascarellMichel AubierVéronique Baron-BodoPhilippe Moingeon

Published in: Immunity, inflammation and disease (2017)

Studying polarized DCs and clinical samples from subjects with or without allergic rhinoconjunctivitis, we demonstrated that the expression of two miRNAs linked to effector DCs (i.e., DC1 and/or DC2 cells), was reduced in the blood of patients with allergic rhinoconjunctivitis. Nevertheless, these miRNAs did not represent relevant biomarkers to predict or follow-up AIT efficacy.

Keyphrases

dendritic cells
regulatory t cells
poor prognosis
immune response
induced apoptosis
binding protein
allergic rhinitis
oxidative stress
signaling pathway
cell proliferation
endoplasmic reticulum stress
type iii