Extracellular vesicles from regenerative human cardiac cells act as potent immune modulators by priming monocytes.
Christien M BeezMarion HaagOliver KleinSophie Van LinthoutMichael SittingerMartina SeifertPublished in: Journal of nanobiotechnology (2019)
CardAP-EVs have useful characteristics that could contribute to enhanced regeneration in damaged cardiac tissue by limiting unwanted inflammatory processes. It was shown that the priming of CD14+ immune cells by CardAP-EVs towards a regulatory type is an essential step to attenuate significantly T cell proliferation and pro-inflammatory cytokine release in vitro.
Keyphrases
- stem cells
- cell proliferation
- induced apoptosis
- left ventricular
- endothelial cells
- small molecule
- cell cycle arrest
- mesenchymal stem cells
- oxidative stress
- cell therapy
- transcription factor
- induced pluripotent stem cells
- dendritic cells
- endoplasmic reticulum stress
- heart failure
- pluripotent stem cells
- bone marrow
- atrial fibrillation