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HBV reactivation in patients with rheumatoid arthritis treated with anti-interleukin-6: a systematic review and meta-analysis.

Stamatia KatelaniGeorge E FragoulisAthanasios-Dimitrios BakasisAbraham PouliakisElena NikiphorouFabiola AtzeniTheodoros Androutsakos
Published in: Rheumatology (Oxford, England) (2023)
Overall, anti-IL-6 treatment comes with a significant risk of HBVr in RA patients with CHB; risk is diminished when antiviral prophylaxis is used. In contrast, in RA patients with resolved HBV infection, the risk of HBVr seems to be extremely low. Large, well-designed studies (either controlled trials or multicentre/international observational studies) are warranted to further validate these results.
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