Emerging Treatment Options for Acute Bacterial Skin and Skin Structure Infections and Bloodstream Infections Caused by Staphylococcus aureus : A Comprehensive Review of the Evidence.
Daniele Roberto GiacobbeSilvia DettoriSilvia CorcioneAntonio VenaChiara SepulcriAlberto Enrico MaraoloFrancesco Giuseppe De RosaMatteo BassettiPublished in: Infection and drug resistance (2022)
Staphylococcus aureus remains an important human pathogen of concern, with mortality rates surpassing 30% in the case of severe systemic infections. Distinguishing methicillin-susceptible S. aureus from methicillin-resistant S. aureus (MRSA) is fundamental for therapeutic choices. A crucial emerging concept in the treatment of acute bacterial skin and skin structure infections is the availability of various approved agents with anti-MRSA activity, which allow a personalized approach based on the characteristics of any given patient while at the same time remaining in line with high certainty efficacy evidence from large randomized controlled trials. Regarding the treatment of S. aureus bloodstream infections (BSI), interesting aspects that may become relevant in the near future are the presence of both old and novel agents in phase-2 or phase-3 of clinical development for this indication, and the pressing need for high certainty evidence to guide the possible use of combination therapy in specific categories or phenotypes of patients with complicated MRSA BSI.
Keyphrases
- staphylococcus aureus
- methicillin resistant staphylococcus aureus
- combination therapy
- biofilm formation
- soft tissue
- wound healing
- liver failure
- randomized controlled trial
- respiratory failure
- endothelial cells
- drug induced
- type diabetes
- risk factors
- coronary artery disease
- clinical trial
- intensive care unit
- case report
- cystic fibrosis
- induced pluripotent stem cells
- hepatitis b virus
- extracorporeal membrane oxygenation
- smoking cessation
- current status
- mechanical ventilation
- drug administration