The numbers of peripheral regulatory T cells are reduced in patients with psoriatic arthritis and are restored by low-dose interleukin-2.
Jia WangSheng-Xiao ZhangYu-Fei HaoMeng-Ting QiuJing LuoYu-Yao LiChong GaoXiao-Feng LiPublished in: Therapeutic advances in chronic disease (2020)
PsA patients exhibited low Treg numbers. Low-dose IL-2 combination treatment increased these numbers and relieved disease activity without any apparent side effects. Additional studies are required to explore the long-term immunoregulatory utility of IL-2 treatment.
Keyphrases
- low dose
- regulatory t cells
- disease activity
- rheumatoid arthritis
- systemic lupus erythematosus
- end stage renal disease
- high dose
- prostate cancer
- ejection fraction
- chronic kidney disease
- rheumatoid arthritis patients
- peritoneal dialysis
- magnetic resonance imaging
- computed tomography
- prognostic factors
- juvenile idiopathic arthritis
- combination therapy
- patient reported
- contrast enhanced