In vitro safety and efficacy evaluation of a novel hybrid bioartificial liver system with simulated liver failure serum.

Lei FengYi WangShusong LiuGuolin HeLei CaiJiasheng QinXiaoping XuZesheng JiangChenjie ZhouYi Gao

Published in: The International journal of artificial organs (2022)

The preparation method for the simulated liver failure serum was optimized successfully, and the safety and effectiveness of the NHBLS in vitro were verified. Furthermore, the NHBLS significantly reduced the levels of Amm which can lead to hepatic encephalopathy.

Keyphrases

liver failure
hepatitis b virus
randomized controlled trial
systematic review
early onset